Brunet, Florent and Gay-Bellile, Vincent and Bartoli, Adrien and Navab, Nassir and Malgouyres, Rémy Feature-Driven Direct Non-Rigid Image Registration International Journal of Computer Vision Springer 2011 93 33-52 The direct registration problem for images of a deforming surface has been well studied. Parametric flexible warps based, for instance, on the Free-Form Deformation or a Radial Basis Function such as the Thin-Plate Spline, are often estimated using additive Gauss-Newton-like algorithms. The recently proposed compositional framework has been shown to be more efficient, but cannot be directly applied to such non-groupwise warps. Our main contribution in this paper is the Feature-Driven framework. It makes possible the use of compositional algorithms for most parametric warps such as those above mentioned. Two algorithms are proposed to demonstrate the relevance of our Feature-Driven framework: the Feature-Driven Inverse Compositional and the Feature-Driven Learning-based algorithms. As another contribution, a detailed derivation of the Feature-Driven warp parameterization is given for the Thin-Plate Spline and the Free-Form Deformation. We experimentally show that these two types of warps have a similar representational power. Experimental results show that our Feature-Driven registration algorithms are more efficient in terms of computational cost, without loss of accuracy, compared to existing methods. http://www.brnt.eu/publications/brunet2011ijcv.pdf 10.1007/s11263-010-0407-x